Erythroplasia of Queyrat is an early form of penis cancer that mainly occurs in elderly uncircumcised male. If left untreated up to 30% of the cases can progress to invasive squamous cell carcinoma of the penis.
What Causes Erythroplasia of Queyrat?
The exact cause of erythroplasia of Queyrat is unclear but there are several conditions that can contribute to the disease, these are:
Chronic infection of the penis
Lack of circumcision
Multiple sex partner
Chronic underlying disease like lichen sclerosis and lichen planus
How does Erythroplasia of Queyrat look like?
Erythroplasia of Queyrat usually seen on glans penis, the prepuce or the urethral meatus in elderly males and may present as single or multiple, non-tender, bright red, non-healing erosions or ulcers. The lesions are often present for months to years before one seek medical attention. It is usually seen in uncircumcised older adults and may be associated with chronic balanoposthitis. Presenting sign and symptoms can vary from individual to individuals and include:
How is Erythroplasia of Queyrat diagnosed?
Although it can be diagnosed clinically by direct examination, biopsy is necessary for a definitive diagnosis.
How is Erythroplasia of Queyrat treated?
Superficial lesions of erythroplasia of Queyrat can be treated with topical 5-fluorouracil and Imiquimod cream that has to be applied for several weeks. Several other treatment modalities have been suggested that are listed below:
Electrodesiccation and curettage
Mohs micrographic surgery
Laser surgery with Carbon dioxide laser ablation or Nd:YAG laser ablation
Photodynamic therapy with aminolevulinic acid